Citrulline Allo. Evaluation of Citrullinemia as a Marker of Bowel Damage After Allogeneic Bone Marrow Transplantation in Children

Evaluation of Citrullinemia as a Marker of Bowel Damage After Allogeneic Bone Marrow Transplantation in Children

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00751452

Enrollment

Registered

2008-09-12

Start date

2008-04-30

Completion date

2009-09-30

Last updated

2011-01-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Benign Disease

Keywords

Children, Allogeneic bone marrow transplantation, Intestinal damage, Citrulline, Graft versus Host Disease, 0 to 18 years old

Brief summary

determine the interest of the dosage of citrullinemia to monitor the bowel damage after allogeneic bone marrow transplantation in children.

Detailed description

30 children included. Dosage of citrullinemia on day -7, day 0 and every week up to 100 days after BMT. Histological examination and extensive infectious screening in case of persistent digestive symptoms (more than 3 days). Two groups of patients regarding on digestive involvement. Comparison of the values of citrullinemia between these two groups.

Interventions

None listed

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

No minimum to 18 Years

Healthy volunteers

Inclusion criteria

* 0 to 18 years * allogeneic bone marrow transplantation for malignant or benign disease * affiliation to French sécurité sociale * parent's consent

Exclusion criteria

* severe gastro-intestinal involvement before transplant * previous digestive surgery

Design outcomes

Primary

Measure	Time frame
Citrullinemia (weekly)	weekly

Secondary

Measure	Time frame
Gastro-intestinal complications in children following allogeneic bone marrow transplantation	following allogenic bone marrow transplantation

Countries

France

Contacts

Primary ContactLacarin Patrick

placarin@chu-clermontferrand.fr

Outcome results