Depression
Conditions
Brief summary
This study will be conducted to determine the pharmacodynamics, cardiovascular and biochemical effects of succinylcholine when given during electroconvulsive therapy. (ECT). This is a single center, prospective, study in patients who will be receiving ECT as indicated and prescribed by their psychiatrist. The study will be performed twice on each patient, 48-72 hours apart during consecutively scheduled ECT procedures.
Detailed description
Patients will receive the anesthetic that is traditionally given which includes appropriate doses of succinylcholine. Serum potassium and creatinine phosphokinase (CK) levels will be determined pre and post anesthesia; serum and urine myoglobin will be determined post anesthesia. Vital signs data \[i.e., heart rate (arrhythmias) and arterial blood pressure\] will be compared pre and post anesthesia. In addition patients will be asked about the presence of muscle pain (myalgia) 1 hour before discharge from the recovery room and the following day post ECT.
Interventions
None listed
Sponsors
University of California, San Francisco
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. A male or non-pregnant female aged 18 years and older 2. American Society of Anesthesiologists physical status 1, 2, 3 3. Scheduled to undergo electroconvulsive therapy under general anesthesia 4. Have given written informed consent
Exclusion criteria
1. Pregnant or nursing 2. Any patient in the study investigators opinion who may not be suitable for research.
Countries
United States
Outcome results
None listed