Fertilization in Vitro, Infertility, Recurrent Implantation Failure
Conditions
Keywords
fertilization in vitro, assisted reproduction, recurrent implantation failure, low molecular weight heparin, heparin, luteal phase
Brief summary
Recurrent implantation failure is the failure to achieve a pregnancy after multiple attempts with in vitro fertilization treatment. The reason is usually obscure. Many empirical treatments have been offered without substantial evaluation. Heparin is thought to play a role in the embryo implantation process beyond its anticoagulation effects. The proposed study aims to assess the effectiveness and safety of empirical administration of low molecular weight heparin in patients undergoing a new IVF treatment cycle after multiple failed attempts.
Interventions
DRUGlow molecular weight heparin (enoxaparine sodium)
1 mg/kg/day subcutaneously in the luteal phase after IVF treatment
DRUGcrinone 8% gel
routine luteal phase support with progesterone gel
Sponsors
V.K.V. American Hospital, Istanbul
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 38 Years
Healthy volunteers
No
Inclusion criteria
* History of at least two previously failed fresh embryo transfer cycles * All previously failed cycles to be performed in the American Hospital of Istanbul * Female age ≤ 38 years * Fresh ejaculate sperms to be used for ICSI * No hormonal, coagulation, or immunological disorders detected * Normal uterine cavity, as assessed by diagnostic office hysteroscopy or saline infusion sonography * Normal female and male peripheral karyotype
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ongoing pregnancy beyond the 20th gestational week rate | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rate | — |
| Embryo implantation rate | — |
Countries
Turkey (Türkiye)
Outcome results
None listed