Infertility
Conditions
Keywords
infertility, IVF, hCG, primary infertility, secondary infertility, patients requiring in-vitro fertilisation
Brief summary
In this study,the investigators compared two protocols for controlled ovarian hyperstimulation in infertility patients requiring IVF. In the control group, the patient undergoes a standard antagonist protocol. In the study group, the administration of gonadotropins is stopped in the late follicular phase and replaced by low dose human chorionic gonadotropins. The primary endpoint of the study is the number of oocytes retrieved in both groups.
Interventions
DRUGhuman chorionic gonadotropin
hCG 200IU in the late follicular phase
200 IU per day during controlled ovarian stimulation
Sponsors
Universitair Ziekenhuis Brussel
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 36 Years
Healthy volunteers
No
Inclusion criteria
* \< 36 years on day of randomisation * FSH \< 12 in the early follicular phase * Normal ultrasound scan * BMI between 18 and 29 (both inclusive) * Randomisation at outpatient clinic
Exclusion criteria
* Endometriosis ≥ grade 3 * PCO syndrome * Poor responder * Endocrine or metabolic abnormalities
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of oocytes in both treatment groups | up to 9 months |
Secondary
| Measure | Time frame |
|---|---|
| Duration of stimulation in both treatment groups, amount of gonadotropins consumed in each treatment group | up to 9 months |
Countries
Belgium
Outcome results
None listed