Evaluation of Toxic Metals, Trace Elements and Total Antioxidant Activity in Children With Recurrent Wheezing

Sectional Prospective Randomised Study of Evaluation Toxic Metals, Trace Elements Status and Total Antioxidant Activity in Children With Recurrent Wheezing.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00749528

Enrollment

Registered

2008-09-09

Start date

2007-09-30

Completion date

2008-07-31

Last updated

2012-03-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthma, Wheezing

Keywords

Wheezing, Hair trace elements, Hair toxic metals, Oxidative stress

Brief summary

The purpose of this study is to evaluate hair trace elements and toxic metals and plasma total antioxidant activity in children with recurrent wheezing and to evaluate whether these toxic metals and trace elements have any impact on serum cytokine levels.

Detailed description

Context: In many studies it was demonstrated that children are much more susceptible than adults for environmental toxic metal exposure. Hair analysis is a promising tool for routine clinical screening and diagnosis of heavy metal exposure and essential trace element states in the human body. Additionally it was demonstrated that oxidants and antioxidants play a central role in the pathogenesis of many pulmonary diseases including asthma. Furthermore, toxic metals, trace elements and oxidative stress have many pivotal role on immune system. Objective: To evaluate and compare hair toxic metals, hair essential trace elements levels and plasma total antioxidant activity between children with recurrent wheezing and age and sex matched healthy children. Intervention: Hair samples will be collected for the analysis of the toxic metals, trace elements. Blood samples will be collected for the analysis of the cytokine levels and plasma antioxidant activity. Study Measures: Differences in hair toxic metals, hair trace elements, plasma cytokine levels and plasma total antioxidant activity will be compared between children with recurrent wheezing and age-sex matched healthy children

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

6 Months to 6 Years

Healthy volunteers

Yes

Inclusion criteria

* Children with recurrent wheezing ages between 6 months to 6 years old. * Age and sex matched healthy children for control group. * Parental/guardian permission (informed consent)

Exclusion criteria

* Systemic corticosteroid use in the last 30 days * Chronic lung diseases including cystic fibrosis * Immunodeficiency * Known renal or hepatic dysfunction * Respiratory truck infections in the last 30 days * Anatomic abnormalities of the respiratory tract * Suspected foreign body aspiration or croup * Immunosuppressive or immunostimulant treatment

Design outcomes

Primary

Measure	Time frame
Hair toxic metal and trace element status in the two groups	6 months

Secondary

Measure	Time frame
To compare plasma total antioxidant activity in the two groups.	6 months
Effect of heavy metals and trace elements on plasma cytokine levels and difference between the two groups	6 months

Countries

Turkey (Türkiye)

Outcome results