Heart Failure
Conditions
Keywords
cardiac resynchronization therapy, echocardiography, heart failure, left ventricular function, pacing, myocardial deformation imaging, Optimal Definition of Left Ventricular Lead Position in Cardiac Resynchronization Therapy
Brief summary
Left ventricular (LV) lead position has crucial impact on cardiac resynchronization therapy (CRT) success. This study will compare fluoroscopy and myocardial deformation imaging for optimal definition of LV lead position.
Detailed description
In a 16 segment model circumferential strain will be used to determine the segment with latest peak systolic circumferential strain prior to CRT, considered as the optimal LV lead target. LV lead will be defined by (1) fluoroscopy, (2) the maximal temporal difference of peak circumferential strain before-to-on CRT and (3) the earliest peak systolic circumferential strain during LV pacing. For all 3 modalities optimal LV lead position is defined as concordance or immediate neighbouring of the segment with defined LV lead position to the determined optimal target segment. At follow-up echocardiography will be performed to determine improvement in LV function and remodeling.
Interventions
PROCEDUREImplantation of a cardiac resynchronization therapy device
PROCEDUREEchocardiography (myocardial deformation imaging)
Sponsors
RWTH Aachen University
Study design
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* See above * Males and females * Ages 18 to 80 years
Exclusion criteria
* Patients who already have had a pacemaker device * Patients with poor echocardiographic window * Patients who are not able to understand the study and to give informed written consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement in LV function and LV remodelling | 6 to 12 months |
Countries
Germany
Outcome results
None listed