Acne Scar, Wrinkle
Conditions
Keywords
Acne scar, Wrinkle, Pigmentation, Fractional CO2 laser
Brief summary
The objective of this study is to investigate the efficacy and side effects of a fractional CO2 laser for treatment of acne scar in Asians.
Detailed description
* The objective of this study is to investigate the efficacy and side effects of a fractional CO2 laser for treatment of acne scar in Asians. * Study hypothesis 1. Reduction in acne scars based on blinded evaluation of before photos and the one and three month follow-up photos after four full face Ellipse Juvia with low density treatments with a fluency of 90-105 mJ/MTZ is statistically significant (5%). 2. The direct clinical blinded evaluated reduction in acne scars based on before photos and the patient in life, by the one and three month follow-up is statistically significant (5%) 3. Reduction in fine lines based on blinded evaluation of before photos and the one and three month follow-up photos after four full face Ellipse Juvia with low density treatments with a fluency of 90-105 mJ/MTZ is statistically significant (5%). 4. The direct clinical blinded evaluated reduction in fine lines based on before photos and the patient in life, by the one and three month follow-up is statistically significant (5%). 5. Reduction in pigmented disorders based on blinded evaluation of before photos and the one and three month follow-up photos after four full face Ellipse Juvia with low density treatments with a fluency of 90-105 mJ/MTZ is statistically significant (5%). 6. The direct clinical blinded evaluated reduction in pigmented disorders based on before photos and the patient in life, by the one and three month follow-up is statistically significant (5%). 7. Improvements in skin texture and pore size based on blinded evaluation of before photos and the one and three month follow-up photos after four full face Ellipse Juvia with low density treatments with a fluency of 90-105 mJ/MTZ is statistically significant (5%). 8. The direct clinical blinded evaluated reduction in skin texture and pore size based on before photos and the patient in life, by the one and three month follow-up is statistically significant (5%).
Interventions
DEVICEFractional CO2 Laser
the treatment settings: 1. Pulse duration : 5 to 7ms depending on skin reaction 2. Spot Density: 49 MTZ/cm2 (Low density) 3. Power: 15 W = (75 - 105) mJ/MTZ
Sponsors
Mahidol University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
25 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* Numbers of volunteers: 10 healthy men and women * Aged at least 30 year old * Skin type: 1 - 4 * Degree of suntan: None - light * Skin condition: visible acne scars
Exclusion criteria
* Fitzpatrick skin types 5-6. * Patients with lesions with any clinical suspicion of being pre-cancerous or skin malignancies of any kind. * Patients with skin diseases associated with Koebner phenomena. * Patients who have used Botox or filler injection to the periorbital or perioral regions 12 months prior or during the study. * Patients who have used topical retinoids, AHA under prescription or Vitamin C, 3 months prior to or during the study. * Patients who are pregnant or who wish to become pregnant and lactating women. * Patients who have been exposed to sun within 2 week from date of treatment. * Patients prone to hypertrophic scars or keloids * Patients who have previously undergone laser resurfacing may not be suitable for yet another procedure. * Patients undergoing oral retinoid therapy for acne in the past 6 months. * Patients who suffer from any serious medical condition, including diabetes, bleeding diathesis, delayed wound healing or prednisolone intake. * Patients with wound infections (herpes, other) on the day of treatment. * Patients with moderate and severe inflammatory acne, Immunosuppressed patients, History of vitiligo. * Patients with unrealistic concerns/expectations and inability to do the appropriate post-operative care.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| by the clinical investigator and graded into one of six categories: worse, no effect, slightly better, fair, good, and excellent. The results shall be reported. | Follow-up 1 and 3 months after the last treatment |
Secondary
| Measure | Time frame |
|---|---|
| The outcome and degree of satisfaction based on the before photo is evaluated by the patients themselves | Follow-up 1 and 3 months after the last treatment |
Countries
Thailand
Outcome results
None listed