Sleep Apnea Syndrome
Conditions
Keywords
Blood pressure, Hypertension, sympathetic control, chemosensitivity, baroreflex
Brief summary
The study is a prospective field evaluation to assess the effects of the chronic Intermittent Hypoxia exposure in 12 healthy humans. Precisely, the study was designed to : Set up a new model of Chronic Intermittent Hypoxia (CIH) applied to healthy human. This CIH is mimicking the CIH undergone by patients suffering from Sleep Apnea Syndrome. Evaluate the cardiovascular effect of CIH. Neuronal and humoral sympathetic control, blood pressure control, vascular resistance. Evaluate the Sleep quality, the ventilation under exposure and the long terms effect on ventilation control of CIH (central and peripheral chemoreflex). Investigates the biological aspects of CIH exposure.
Interventions
OTHERChronic Intermittent Hypoxia
Chronic Intermittent Hypoxia mimicking the CIH undergone by patients suffering from Sleep Apnea Syndrome, is applied to Healthy subject during 8 hours a day (nights) for a 14 days period. The cycle of intermittent Hypoxia is 30 drop in SaO2 per hours with a 10% decrease in SaO2.
Sponsors
University Hospital, Grenoble
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Healthy subjects
Exclusion criteria
* Any history or significant medical condition
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood Pressure | Two Weeks |
Secondary
| Measure | Time frame |
|---|---|
| Neuronal and humoral sympathetic control and vascular resistance. | Two weeks |
| Sleep quality | Two Weeks |
| The ventilation under exposure and the long terms effect on ventilation control of CIH (central and peripheral chemoreflex) | two weeks |
Countries
France
Outcome results
None listed