Rhinitis, Allergic, Seasonal
Conditions
Keywords
birch pollen
Brief summary
Birch pollen allergy is one of the most common forms of respiratory allergy in the Nordic countries. Treatment consists of antihistamine use. Specific probiotic strains have been observed to modulate the immune system. Since the body has a common mucosal immune system; it was hypothesised that consumption of probiotics may affect also the respiratory mucosal immune response and hence affect respiratory allergy. Earlier studies with probiotics had been unable to show improvements in adults with pollen allergy. It was therefore hypothesised that children, who's immune system is not yet fully developed, might be better targets.
Interventions
Daily 5x10\^9 CFU of a combination of L. acidophilus and B. lactis
BIOLOGICALPlacebo
Microcrystalline cellulose As capsule which could be opened
Sponsors
Danisco
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
2 Years to 10 Years
Healthy volunteers
No
Inclusion criteria
Physician verified birch pollen allergy
Exclusion criteria
Diagnosed asthma Habitual use of probiotics and/or prebiotics
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Birch pollen allergy symptoms | March/April and June |
| Nasal Eosinophilia | April/May and June |
Secondary
| Measure | Time frame |
|---|---|
| Change in microbiota composition | April/May and June |
| Cytokine profile from serum | April/May and June |
| Faecal recovery of administered probiotics | April/May and June |
Countries
Finland
Outcome results
None listed