Measurement of MRP2 Function Using Urinary Coproporphyrins

Evaluation of the Ratio of Urinary Coproporphyrins I and III as a Potential Biomarker of MRP2 Function in Man

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00746044

Acronym

COVOL

Enrollment

Registered

2008-09-03

Start date

2008-02-29

Completion date

2009-04-30

Last updated

2009-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Subjects

Keywords

Healthy

Brief summary

Human Multidrug Related Protein 2 (MRP2) excretes several drugs and could therefore modulate their elimination. Individual's MRP2 activity is under genetic control. Thus it would be very useful to get an easily measurable biomarker reflecting individual's MRP2 activity. We aimed to investigate the ratio of urinary coproporphyrins I and III (UCP(I/I+III), known to be increased in patients with mutations in MRP2/ABCC2 gene.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy * \> 18 y * Affiliated to an health insurance

Exclusion criteria

* Patient not able to understand or to comply to the protocol

Design outcomes

Primary

Measure	Time frame
Urinary coproporphyrins (I/I+III)ratio	End of three 24-hours periods

Secondary

Measure	Time frame
ABCC2 polymorphisms	At the time of entering in the study

Countries

France

Outcome results