The LAMA Trial: Laparoscopic Correction of Perforated Peptic Ulcer Versus Open Correction

The LAMA Trial: Laparoscopic Correction of Perforated Peptic Ulcer Versus Open Correction by Upper Laparotomy

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00745667

Acronym

LAMA

Enrollment

109

Registered

2008-09-03

Start date

1999-07-31

Completion date

2007-01-31

Last updated

2008-09-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perforated Peptic Ulcer

Keywords

laparoscopic, peptic ulcer

Brief summary

This is a multicenter trial comparing laparoscopic correction of a perforated peptic ulcer with the open technique by upper laparotomy. Hypothesis is that after laparoscopic correction will be discharged 3 days sooner due to less postoperative pain and complications.

Detailed description

as written above

Interventions

PROCEDURElaparoscopic surgery

laparoscopic correction perforated peptic ulcer

PROCEDUREUpper laparotomy

upper laparotomy for correction of perforated peptic ulcer

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* All patients clinical suspected for perforated peptic ulcer

Exclusion criteria

* Pregnancy * Younger than 18 years * Unable to sign consent form

Design outcomes

Primary

Measure	Time frame
days of discharge	7 days

Secondary

Measure	Time frame
postoperative VAs pain score and opiate usage; postoperative complications; Quality of live (RAND 36, euroquol)	follow up 1 year

Countries

Netherlands

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026