The Effect of Infliximab on Sperm Quality

The Effect of Infliximab,Adalimumab, Azathioprines and 5-Aminosalicylate on Semen Quality in Men With Inflammatory Bowel Disease

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00745329

Enrollment

100

Registered

2008-09-03

Start date

2008-10-31

Completion date

Unknown

Last updated

2008-09-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Crohn's Disease, Ulcerative Colitis

Brief summary

Background: The treatment of inflammatory bowel diseases (IBD) is based mainly on 3 compounds: 1- 5 aminosalysilates . 2- immunomodulators (Azathioprines). 3- Biologic therapies (Infliximab, Adalimumab) . There are no established data in the literature whether these therapies effects sperm quality. Given that a large number of the patients are young men in the reproductive stage of their lives , It of importance to investigate these effect. Aim: To investigate the effect of chronic treatment of any of the three therapy mentioned above, on sperm quality .

Interventions

OTHERsperm quality test

All participants will undergo sequential sperm quality tests and blood tests

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

MALE

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Male above the age of 18 * Capable of giving informed consent * Diagnosed with IBD at least 3 months * Patients that are going to start a treatment with on of the following groups: 5ASA, Azathioprines, infliximab or ADAlimumab * Patients that are treated with therapies mentioned in article 4 for at least 3 months

Exclusion criteria

* Male younger than 18

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026