Impulsivity, Neural Deficits and Cocaine Addiction

Impulsivity, Neural Deficits, and Relapse in Cocaine Addiction

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00744601

Enrollment

Registered

2008-09-01

Start date

2007-04-30

Completion date

2012-09-30

Last updated

2013-01-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cocaine Dependence

Keywords

impulsivity, cocaine dependence, relapse, neuroimaging, functional magnetic resonance imaging (fMRI), single photon emission computed tomography (SPECT)

Brief summary

The purpose of this study is to assess neurocognitive and associated neural regions/circuitry disruptions relevant to impulsive relapse in cocaine-addicted subjects, and the relationship of the cognitive and neural mechanisms of impulsivity/decision-making to relapse style.

Detailed description

This study is designed to explore putative differences in impulsive behaviors and decision making in cocaine-addicted and healthy control subjects using functional magnetic resonance imaging (fMRI), single photon emission tomography (SPECT), and neurocognitive tasks. We predict that cocaine-addicted subjects will demonstrate neurocognitive and neural alterations in measures of impulsivity and decision-making when compared to healthy controls. That is, cocaine-addicted subjects will show both decreased activation and decreased resting measures of regional cerebral blood flow (rCBF) of the brain structures associated with impulsivity and decision-making. Furthermore, neurocognitive and neural deficits associated with impulsivity and decision-making will be associated with each other and with measures indicative of an impulsive relapse and altered decision making.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

21 Years to 55 Years

Healthy volunteers

Yes

Inclusion criteria

* Cocaine-dependence (patient population) or no cocaine-dependence (control population).

Exclusion criteria

* Other medical or psychiatric disorders that may effect neural functioning. * Medications that may effect neural functioning.

Design outcomes

Primary

Measure	Time frame
Determine if the brain regions involved in inhibition and decision-making are altered in cocaine-addicted subjects compared to healthy controls.	2 weeks
In cocaine-addicted subjects, determine if neural deficits during disinhibition or decision-making are related to relapse following treatment.	6 months

Secondary

Measure	Time frame
Assess the predictive validity of self-report measures of impulsive relapse.	6 months

Countries

United States

Outcome results