Prospective Comparison of Immunological Benefit of Laparoscopic Colectomy

Prospective Comparative Study of Immunological Benefit Between Laparoscopic Colectomy and Open Colectomy

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00744159

Enrollment

Registered

2008-08-29

Start date

2006-01-31

Completion date

2007-11-30

Last updated

2008-08-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Immunity

Keywords

colon cancer, laparoscopic colorectal surgery, cellular immunity, HLA-DR expression on monocyte

Brief summary

This study aimed to clarify existence of immunological benefit of laparoscopic colon cancer surgery compared to open colon surgery.

Detailed description

Patients with clinical stage Ⅲ left colon and upper rectal cancer were prospectively assigned to undergo LC (n=35) or OC (n=39). Factors related to cellular immunity of host (total lymphocyte count, CD4 lymphocyte, CD8 lymphocyte, CD4/CD8 ratio, HLA-DR expression on monocyte (mHLA-DR)) were examined preoperatively, on the 1st day of operation (POD1) and the 5th day of operation (POD5).

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Biopsy proven of colon cancer * Preoperatively suspected as clinical stage III colon cancer * Lesion located Descending colon, sigmoid colon and upper rectal cancer

Exclusion criteria

* Could not perform curative resection * Intestinal obstruction, perforation, intra-abdominal abscess * Severe medical illness * Immunopathy

Design outcomes

Primary

Measure	Time frame
Immune factors	post OP 5th day

Secondary

Measure	Time frame
Post-operative complications	POD 7th days

Countries

South Korea

Outcome results