Influence of Plasma Rich in Growth Factors (PRGF) on Healing of Medial Collateral Ligament (MCL) Tear

Influence of PRGF on Healing of MCL Tear - Randomized-Double-Blind-Placebo Control Trail

Status

Withdrawn

Phases

Phase 2Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00743886

Enrollment

Registered

2008-08-29

Start date

2008-01-31

Completion date

2009-03-31

Last updated

2011-07-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

MCL Tear

Brief summary

To evaluate the influence of Plasma Rich in Growth Factors (PRGF) on the healing process of medial collateral ligament (MCL) tear.

Detailed description

Autologous platelet-rich matrices may aid in the healing of ligaments & tendons by promoting and accelerating tissue healing because of the release of growth factors including transforming growth factor (TGF)-beta1 and platelet-derived growth factor (PDGF) from platelet alpha-granules.

Interventions

BIOLOGICALPlasma Rich in Growth Factors (PRGF)

injection onto injured area in ligament dose: 3-6mg

DRUGsaline

injection of 6 cc of saline into injured area

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 40 Years

Healthy volunteers

Inclusion criteria

* age 18-40 years old * diagnosed MCL tear grade 2/3

Exclusion criteria

* pregnancy * mental or physical disabilities

Design outcomes

Primary

Measure	Time frame
time and efficiency of healing	1 year

Countries

Israel

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026