Bronchiolitis Obliterans, Death, Lung Transplantation, Rejection
Conditions
Keywords
Lung transplantation, Home spirometry, non-adherence, outcomes, bronchiolitis obliterans
Brief summary
Prospective cohort, mono-center study included electronic data of home spirometry (HS, lung function) of lung transplant recipients
Detailed description
Study period between 1/2/2000 and 31/12/2003 Follow-up until 31/12/2007 Patient will be stratified according to adherence to HS during the first 2 postoperative years Good adherent patient: patient performed ≥ 80% of predicted HS within 24 months Moderate adherent patient: patient performed ≥ 50% of predicted HS within 24 months Non-adherent patient: patient performed \< 50% of predicted HS within 24 months. Primary outcome measure graft loss at end of follow-up Secondary outcome measure number of acute rejections during follow-up number of hospitalisation during follow-up Incidence of bronchiolitis obliterans syndrome during follow-up
Interventions
None listed
Sponsors
Hannover Medical School
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Any type of lung transplant incl single, double, combined and re-do * \> 18 years of age * LTx or HLTx ≥ 6mts post Tx * Stable health condition at study entry (pt stays within home environment) * Sufficient language skills for AMOS training * Successful AMOS training * Follow-up at our center (≥6 mts post LTx) * Willingness to participate by informed consent
Exclusion criteria
* Refused consent * BOS diagnosis before study inclusion * Malignancy before study inclusion * Loss for follow-up (≤ 6 mts after study inclusion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Graft loss | 3 year |
Secondary
| Measure | Time frame |
|---|---|
| BOS | 3 year |
| Number of acute rejections | 3 year |
| Number of hospitalizations | 3 year |
Countries
Germany
Outcome results
None listed