Effects of the Soluble Mediators of Mastocytes on the Intestinal Epithelial Barrier and of the Enteric Nervous System During the Syndrome of the Irritable Bowel

Effects of the Soluble Mediators of Mastocytes on the Intestinal Epithelial Barrier and of the entérique Nervous System During the Syndrome of the Irritable Bowel

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00742118

Enrollment

200

Registered

2008-08-27

Start date

2008-02-13

Completion date

2016-08-24

Last updated

2026-06-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Irritable Bowel Syndrome

Brief summary

Patients with irritable bowel syndrome (IBS) have increased intestinal permeability. In addition, mucosal soluble mediators are involved in the pathophysiology of pain in IBS. The investigators aimed to investigate: 1. paracellular permeability in colonic biopsies of IBS patient 2. the ability of soluble factors from colonic biopsies to reproduce in vitro these alterations

Interventions

PROCEDUREColic biopsies

colic biopsies and analysis

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Patients needing coloscopy

Exclusion criteria

* Disrupted coagulation results * Cancer even healed * Known food allergy. * Alcohol consumption \>30g/day

Design outcomes

Primary

Measure	Time frame
Para-cellular permeability	at time=0
Gap junction protein expression	at time=0
Inflammation molecule expression	at time=0
Digestive discomfort degree	at time=0

Countries

France

Contacts

PRINCIPAL_INVESTIGATORThierry PICHE, PhD

Department of Gastroenterology

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 17, 2026