Role of AT1-receptor Blockers in Insulin-induced Vasodilation.

Insulin-induced Microvascular Activity in Patients With Essential Hypertension: a Possible Role for Angiotensin II AT1-receptor Blockers.

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00742066

Enrollment

Registered

2008-08-27

Start date

2008-03-31

Completion date

2009-07-31

Last updated

2011-03-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension, Insulin Resistance, Microcirculation

Keywords

Hypertension, Insulin resistance, Microcirculation, Angiotensin II receptor blocker

Brief summary

In this study we hypothesize that blocking the angiotensin II AT1-receptor improves the insulin-induced microvascular dilatation. Objectives: 1. Does blockade of the angiotensin II AT1-receptor improve the insulin-induced microvascular effects in hypertensive patients. 2. Does blockade of the angiotensin II AT1-receptor impair the insulin-induced microvascular effects in normotensive control subjects?

Interventions

DRUGIrbesartan

Single dose 600mg orally

DRUGFelodipine

single dose 10mg Felodipine ER

DRUGPlacebo

Single dose tablet orally

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

hypertensive subjects: 1. 18-60 years 2. Caucasian 3. untreated hypertension \>140/90mmHg. normotensive subjects: 1. 18-60 years 2. Caucasian 3. Blood pressure \<140/90 mmHg.

Exclusion criteria

1. Obesity (BMI\>27kg/m2) 2. Cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, heart failure) 3. Impaired glucose tolerance or diabetes mellitus according to the criteria of the ADA 4. Smoking 5. Alcohol use \>4U/day 6. Use of medication (antihypertensive drugs, lipid lowering drugs, corticosteroids, NNSAIDs) 7. Pregnancy 8. Wearing contact lenses

Design outcomes

Primary

Measure	Time frame
functional recruitment of capillaries in the skin	July 2009

Secondary

Measure	Time frame
perfused capillary density in the nailfold	July 2009
Endothelium- (in)dependent vasodilatation of finger skin microcirculation	July 2009
Density of arterioles, capillaries and venules in the bulbar conjunctiva.	July 2009
Diameter of arterioles and venules in the bulbar conjunctiva	July 2009

Countries

Netherlands

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026