Blood Pressure, Cardiovascular Disease, Community Based Study, Sudden Death
Conditions
Keywords
epidemiology, risk factors, heart rate, baroreflex sensitivity, sudden death
Brief summary
The aim of the present Paris Prospective Study III (PPS3) is (1) to assess the determinants of the regulation of heart rate and blood pressure variations and carotid properties (under different physiologic stimulations) and (2) to evaluate the respective contribution of heart rate, blood pressure variations and carotid properties to cardiovascular morbidity and mortality including sudden death during 10 years at least in healthy considered subjects.
Detailed description
Overall, 10 157 men and women have been recruited during May 2008 and June 2012 for an extensive clinical examination including a 2h holter electrocardiography (ECG), a carotid doppler echo tracking, a step test, as well as blood and DNA collections. Since then, the cardiovascular morbidity and mortality of the participants is being followed up for 10 years at least and will continue up to 2032.
Interventions
OTHERSpider flash ECG, high-precision carotid echo-tracking, step test
cardiac rhythm recorded during health check up, vascular aging parameters and baroreflex sensitivity recorded during carotid echotracking of the right common carotid artery , step test during 2 minutes
Sponsors
Institut National de la Santé Et de la Recherche Médicale, France
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
50 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* 50-75 years, French speaking, given consent for genetic analysis, * written consent for participating in the study
Exclusion criteria
* \<50 years and \>75 years, * no French speaking, * current pregnancy, * chronic severe disease, * disagreement for genetic analysis, * step test considered as non possible or non advisable by medical decision.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| cardiovascular disease (CVD) | through study completion, an average of 24 years | incident coronary heart disease (CHD), stroke, sudden death, mortality |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| heart rate parameters and baroreflex sensitivity | 4 Years | as measured on the Spider Flash ECG and the carotid echotracking |
| other CVD outcomes | through study completion, an average of 24 years | heart failure, arterial aneurysms, venous thromboembolism (VTE), pulmonary embolism, arrhythmic events (atrial fibrillation, flutter) |
Countries
France
Contacts
STUDY_DIRECTORXavier Jouven, MD, PhD
INSERM and APHP
PRINCIPAL_INVESTIGATORJean-Philippe Empana, MD, PhD
Institut National de la Santé Et de la Recherche Médicale, France
PRINCIPAL_INVESTIGATORPierre Boutouyrie, MD, PhD
INSERM and APHP
Outcome results
None listed