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Corrected Measurement of the Retinal Nerve Fiber Layer Thickness by Optic Disc Configuration With the Cirrus HD OCT

Corrected Measurement of the Retinal Nerve Fiber Layer Thickness by Optic Disc Configuration With the Cirrus HD OCT

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT00741130
Enrollment
50
Registered
2008-08-26
Start date
2008-07-31
Completion date
2009-01-31
Last updated
2008-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glaucoma, Myopia

Keywords

retinal nerve fiber layer, optic nerve head, Cirrus OCT

Brief summary

Because the measurement of the retinal nerve fiber layer thickness is very sensitive to the position of measurement, it may be incorrect in patients with the tilted disc. In the present study, the corrected RNFL thickness by the optic nerve head configuration using the Cirrus HD OCT will be evaluated. If the corrected RNFL thickness is more sensitive to detect the localized RNFL defect, the present software should be upgrade to reflect the optic nerve head configuration.

Detailed description

Finding the localized retinal nerve fiber layer (RNFL) defect and measuring the RNFL thickness are two main issues for early glaucoma detection. A recently developed imaging device, the Cirrus HD OCT, offers more detailed informations about retina architecture including optic nerve head. To calculate the RNFL thickness, the software of the Cirrus HD OCT supposes an ideal optic nerve head. However, in the cases with not ideal optic disc configuration, the measurement of the RNFL thickness is not correct. Because the measurement of the RNFL thickness is extremely sensitive to the position of measurement, patients with the tilted disc are in danger of misdiagnosis. In the present study, we want to correct the RNFL thickness measurement according to the optic nerve head configuration using the Cirrus HD OCT. If the corrected RNFL thickness is more sensitive to detect the localized RNFL defect, the present software should be upgrade to reflect the optic nerve head configuration.

Interventions

None listed

Sponsors

Yonsei University
Lead SponsorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes

Inclusion criteria

* normal controls or glaucoma patients * signal intensity of the OCT image \> 8 * cooperative subjects

Exclusion criteria

* spherical equivalent refractive errors \> +4 diopters or \< -4 diopters * significant media opacity * previous intraocular surgery

Design outcomes

Primary

MeasureTime frame
the Cirrus HD OCTwhen the OCT images are taking

Secondary

MeasureTime frame
automated visual fieldwhen the OCT images are taking
red-free fundus photowhen the OCT images are taking
refractive errorswhen the OCT images are taking

Countries

South Korea

Contacts

Primary ContactGong Je Seong, MD, PhD
gjseong@yuhs.ac82-2-2019-3441

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026