Liver Disease, Hyperbilirubinemia
Conditions
Keywords
Pulse Oximetry, Blood Gas Analysis, Liver Disease, Hyperbilirubinemia
Brief summary
The purpose of this study is to determine if higher levels of bilirubin in the blood of people with liver disease affects how accurate a pulse oximeter machine is able to measure the concentration of oxygen in the blood. Previous studies have reported conflicting results regarding the affect of high levels of bilirubin in the blood on the accuracy of the pulse oximeter reading. Initial studies showed an underestimation of the oxygen concentration in the presence of elevated bilirubin. Subsequent studies have suggested that high levels of bilirubin in the blood do not influence the accuracy of the pulse oximeter machine. However, recent reports in bone marrow transplant literature and our personal observations in patients with liver disease suggest that high bilirubin levels are associated with an overestimation of the oxygen concentration as measured by the pulse oximeter machine.
Interventions
PROCEDUREArterial Blood Gas
One blood gas sample will be obtained from an artery in the arm.
PROCEDUREPulse Oximetry Machine
A pulse oximetry machine will be used at one time point to obtain an oxygen saturation reading. This is done by placing a clip onto the finger. The pulse oximetry value displays on the pulse oximeter machine within seconds.
PROCEDUREDirect and Indirect Serum Bilirubin Measurement
One tube of blood will be drawn from a vein in the arm at one timepoint to measure the direct and indirect serum bilirubin levels.
Sponsors
Emory University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with established liver disease or dysfunction, as determined by abnormal liver function tests, imaging, or biopsy
Exclusion criteria
* Patients with unconjugated hyperbilirubinemia, which could be associated with elevations in carboxyhemoglobin * Patients with poor peripheral perfusion that would compromise accurate pulse oximetric determination
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of pulse oximetric saturation and calculated oxygen saturation. | Enrollment visit |
Countries
United States
Outcome results
None listed