Acute Effects of Smoking on Airway Dendritic Cells

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00740896

Enrollment

Registered

2008-08-25

Start date

2008-06-30

Completion date

2008-12-31

Last updated

2009-04-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tobacco Use Disorder

Keywords

Cigarette Smoking, Airway dendritic cells

Brief summary

Airway dendritic cells control pulmonary immune responses to inhaled particles. It is the aim of the present study to investigate the acute effects of smoking on the number and surface molecule expression of human airway dendritic cells.

Interventions

BEHAVIORALSmoking

Active Comparator: Participants smoke 8 cigarettes in 4 hours.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Active smoking (at least 10 cigarettes per day) * Age \> 18 years

Exclusion criteria

* Any chronic diseases * Any regular medication * Any signs or symptoms of an acute infection

Design outcomes

Primary

Measure	Time frame
Total number of dendritic cells in bronchoalveolar lavage fluid	June - September 2008

Secondary

Measure	Time frame
Surface molecule expression on dendritic cells in bronchoalveolar lavage fluid	June - September 2008

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026