Abdominal Aortic Aneurysm
Conditions
Keywords
Aneurysm, Rupture
Brief summary
The purpose of this study is to identify possible in vivo biochemical and biological markers related to aortic wall strength.
Detailed description
Rupture of an Abdominal Aortic Aneurysm (AAA) is potentially lethal. prophylactic surgical repair is therefore warranted when the risk of rupture exceeds the risk of complications following surgery. Aneurysm rupture occurs when the forces (stress) acting on the aneurysm wall surpass aneurysm wall strength. Information on both wall stress and strength might therefore improve rupture risk assessment and patient selection for prophylactic repair. Although aneurysm wall stress calculations are possible, no in vivo method exists to determine aneurysm wall strength. This study was designed to identify possible biomarkers of aneurysm wall strength
Interventions
None listed
Sponsors
Radboud University Medical Center
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient scheduled for transabdominal aortic surgery
Exclusion criteria
* Patient characteristics and aneurysm anatomy suitable for endovascular repair * Previous aortic surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Aneurysm wall strength | Post-operative |
Secondary
| Measure | Time frame |
|---|---|
| Extra Cellular Matrix components (Glucoaminoglycans) | post-operative |
| Biochemical blood analysis | post-operative |
| MMP content | post-operative |
| Degree of inflammation | Post-operative |
Countries
Netherlands
Contacts
Primary ContactMaarten Truijers, MD
Outcome results
None listed