Cognitive Performance
Conditions
Keywords
TMS, fMRI, verbal working memory, classical conditioning, eyeblink, classical eyeblink conditioning, Healthy subjects, Memory
Brief summary
Functional neuroimaging studies have shown that the cerebellum is active during cognitive performance. The investigators hypothesize that stimulation of the cerebellum with transcranial magnetic stimulation will produce brief changes in performance of the task, suggesting that cerebellar activation is necessary for normal cognitive function.
Interventions
DEVICECerebellar transcranial magnetic stimulation
single pulse TMS or repetitive TMS at 1 Hz frequency
Sponsors
National Institute of Mental Health (NIMH)
National Institute on Aging (NIA)
Johns Hopkins University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
19 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* 19-30 years of age * Informed consent
Exclusion criteria
* History of seizure or a family history of epilepsy * History of stroke * Presence of metal anywhere in the head except the mouth * Presence of cardiac pacemakers * Presence of cochlear implants * Presence of implanted medication pump * History of heart disease * Presence of intracardiac lines * Increased intracranial pressure, such as after infarctions or trauma * Children, or outside of age range * Pregnancy * Currently taking tricyclic anti-depressants or neuroleptic medication * History of head trauma * History of respiratory disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Behavioral performance (accuracy, or rate of conditioned responses) | during computerized task performance (2 hours) |
Secondary
| Measure | Time frame |
|---|---|
| Reaction time | during performance of computerized task (2 hours) |
Countries
United States
Outcome results
None listed