Once Daily vs Twice Daily Administration of Gonadotropins in Assisted Reproductive Technologies (ART)

A Prospective Randomized Study of QD vs BID Dosing in ART

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00740025

Acronym

QD vs BID

Enrollment

200

Registered

2008-08-22

Start date

2006-01-31

Completion date

2010-01-31

Last updated

2010-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnancy

Keywords

QD dose, BID dosing, peak estradiol, oocytes, implantation rate, pregnancy rate

Brief summary

This is a prospective randomized study evaluating dosing frequency of gonadotropin administration in ART cycles.

Detailed description

Using once daily or bid dosing of gonadotropins in ART has been arbitrary with no studies showing whether splitting the medication dose improves ART parameters. This study was undertaken to provide an answer to this important question.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

21 Years to 39 Years

Healthy volunteers

Inclusion criteria

* women \< 40 undergoing ART

Exclusion criteria

* women \> 40 * endometriomas * severe cervical stenosis * testicular sperm

Design outcomes

Primary

Measure	Time frame
Ongoing pregnancy	1 year

Secondary

Measure	Time frame
peak estradiol, number of follicles, number of oocytes, implantation rate, multiple pregnancy rate	1 year

Countries

United States

Outcome results