Posttraumatic Stress Disorder
Conditions
Keywords
posttraumatic stress disorder, electroconvulsive therapy, medication refractoriness
Brief summary
Post Traumatic Stress Disorder is a chronic debilitating illness and few treatment options have demonstrated effectiveness. The study will look at the use of electroconvulsive therapy for the treatment of Post Traumatic Stress disorder in patients who have not responded to multiple antidepressants or cognitive behavioral therapy.
Interventions
PROCEDUREElectroconvulsive Therapy
ECT was administered using the MECTA-SR1 apparatus. The current amplitude was 800 mA, pulse width was 1.5 ms, and pulse frequency was 50 Hz. Stimulus duration was increased as required to elicit an adequate seizure, defined as at least 25 s with EEG monitoring. The ECT course was fixed, and comprised 6 treatments administered with bitemporal electrode placement at a twice-weekly frequency
Sponsors
Government Psychiatric Diseases Hospital, Srinagar
Government Medical College Srinagar
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosis of PTSD * Treatment resistance to 4 different antidepressants from 3 different classes * Treatment resistance to CBT * Severe PTSD
Exclusion criteria
* Significant substance abuse * Pregnancy * History of Traumatic Brain Injury * Unstable comorbid medical illness * Organic brain syndrome
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinician-Administered Posttraumatic Stress Disorder Scale (CAPS) SCORE | — |
Secondary
| Measure | Time frame |
|---|---|
| Montgomery-Asberg Depression Rating Scale score | baseline, 48 hrs post 3rd, 6th ECT |
Countries
India
Outcome results
None listed