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Early Enteral Feeding After Intestinal Anastomosis

Early Enteral Feeding After Intestinal Anastomosis

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00739271
Enrollment
82
Registered
2008-08-21
Start date
2005-10-31
Completion date
2007-12-31
Last updated
2008-08-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intestinal Anastomosis

Brief summary

The concept of starting the patient on early enteral nutrition has been a topic of much interest and research in the past decade. It is gaining widespread acceptance worldwide as more and more studies are being conducted proving early enteral nutrition to be more physiological, to prevent morphologic and functional trauma related alterations of the gut and to modulate immune and inflammatory responses, and as being less expensive than total parenteral nutrition. Early enteral nutrition is a major component of the recently introduced post operative rehabilitative regimens. Early feeding has been shown to reduce the risk of any specific infection, mean length of hospital stay, anastomotic dehiscence, wound infection, pneumonia, intra abdominal abscesses. It leads to lower weight loss and early positive nitrogen balance. Hence, overall early enteral nutrition leads to reduced post operative morbidity and better patient outcome. The objective of this study was to study and compare the effects of early enteral feeding with those of conventional management in patients undergoing intestinal anastomosis; the end points being return of bowel activity, incidence of septic complications, length of hospital stay, weight loss and post operative morbidity.

Detailed description

Pre operatively, common parameters observed in both study and control groups were: * Name * Age * Sex * Date of admission * Weight * Indication of surgery * Pre operative features of sepsis (whether present or not) which included temperature, pulse rate& total leukocyte count. Post operatively, the patients in the study group were kept nil per orally for the first forty eight hours. The nasogastric tube was removed on the first post operative day invariably. After forty eight hours of surgery, subjects were started on sips of clear liquids orally; the amount was gradually increased as tolerated by the patient. The diet was stepped up to soft diet and to regular diet. A record was made of abdominal discomfort, pain or distension if experienced by the subject during feeding. Record was made of the following: * Site of anastomosis * Type of anastomosis ( sutured / stapled ) * Time of removal of nasogastric tube * Time of passage of flatus / stools post operatively * Time of appearance of bowel sounds * Features of sepsis which included temperature, pulse rate & total leukocyte count * Presence of wound infection * Weight on the fifth day of surgery, at the time of discharge * Date of discharge * Length of hospital stay Patients in the control group were kept on maintenance intravenous fluids containing dextrose and saline. Nasogastric tube was removed and feeds were started orally as decided by the operating surgeon depending on the clinical condition of the patient and presence of bowel activity. Post operative records were made of the same parameters as in the study group.

Interventions

OTHERlate feeding after bowel sounds return

Traditional method

Sponsors

Christian Medical College and Hospital, Ludhiana, India
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
12 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* All patients undergoing intestinal anastamosis on an elective or emergency basis

Exclusion criteria

* Re laparotomies * Patients who are immunosuppressed * Patients with renal failure * Patients with spinal injuries * Patients requiring critical care * Pediatric patients

Design outcomes

Primary

MeasureTime frame
To be able to tolerate early enteral feed48 hours

Countries

India

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026