Clinical Pregnancy Rate, Infertility
Conditions
Keywords
Infertility, Clinical pregnancy rate
Brief summary
Endometrial sampling improves the pregnancy rates in superovulation-IUI cycles
Detailed description
Endometrial sampling is performed using the standard technique in the outpatient department. Similarly, superovulation with gonadotrophins will be performed according to our standard practice.Endometrial sampling will be done in the follicular phase not later than day 10 of the cycle. Endometrial sampling will be performed using Pipelle sampling catheter. The Pipelle is inserted gently through the cervical canal into the uterine cavity and advanced slowly till just resistance felt by the operator. Then, the piston is withdrawn to create negative suction and gentle movement of Pipelle up and down in the uterine cavity is performed while it is against the uterine wall. The Pipelle catheter is withdrawn gently and any obtained specimen will be sent for histopathological examination.
Interventions
PROCEDUREEndometrial sampling
Endometrial sampling performed in the preceding cycle. It will be done in the follicular phase not later than day 10 of the cycle
Sponsors
McGill University Health Centre/Research Institute of the McGill University Health Centre
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
1. All women undergoing superovulation with gonadotrophins and intrauterine insemination. 2. All women with cervical factor, mild male factor and/or unexplained infertility. 3. At least one patent Fallopian tube.
Exclusion criteria
1. Bilateral tubal disease 2. Severe male factor infertility 3. Intrauterine pathology (submucosal fibroid, endometrial polyp, adhesions) 4. Women with positive cervical culture and/or acute vaginal infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The rate of clinical pregnancy | 24 months |
Countries
Canada
Outcome results
None listed