Memory and Picture Viewing Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00736203

Acronym

MPVS

Enrollment

116

Registered

2008-08-15

Start date

2008-07-31

Completion date

2011-11-30

Last updated

2013-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brain Reactivity of Non-smokers Undergoing fMRI Scanning, Healthy

Keywords

fMRI, non-smokers

Brief summary

The purpose of this study is to obtain a database of brain function from a sample of non-smokers while they do tasks in an MRI (magnetic resonance imaging) machine. Our hypothesis is that among nonsmokers, reactivity to smoking cues will be highly similar to control cues but may vary as a function of attitudes toward smoking and/or family history of smoking. We also hypothesize that brain activity during the n-back task will be more similar to data collected during this task when smokers are not abstinent.

Detailed description

Thirty six non-smokers will undergo functional magnetic resonance imaging (fMRI) scanning. During scanning participants will complete the n-back task-a measure of working memory-and the cue-reactivity task-a measure of responses to smoking cues. Before scanning, participants will complete a training session where they will be familiarized with the tasks. All participants will have to pass a screening visit in order to be included in the study.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 55 Years

Healthy volunteers

Yes

Inclusion criteria

* generally healthy * right-handed non-smokers * between the ages of 18-55 * an expired CO concentration of 5 ppm or less; or a negative urine cotinine test of 100 ng/mL or less (to confirm a non-smoker) * having smoked \< 50 cigarettes in their lifetime

Exclusion criteria

* inability to attend all sessions * significant health problems (hypertension, emphysema, seizure disorder, history of significant heart problems) * use of psychoactive medications * use of any tobacco or nicotine containing products * current alcohol or drug abuse * use of illegal drugs as measure by a urine drug screen * presence of conditions that would make MRI unsafe (pacemaker, metallic implants

Design outcomes

Primary

Measure	Time frame
brain reactivity	3 weeks

Countries

United States

Outcome results