Low Back Pain
Conditions
Keywords
low back pain, chronic, Substance P
Brief summary
The purpose of this study is to compare the levels of Substance P in saliva, in patients with severe chronic low back pain and in subjects without it. In addition, to explore a possible cutoff point, in order to define normal and pathological levels of Substance P in saliva. The ultimate objective would be to design a measurement method for use in routine clinical practice.
Interventions
OTHERThe taking of a saliva sample from each subject.
After taking the sample, the saliva will be transferred via a pipette to a clean tube which will be labeled with the subject's name, the date and the hour. Once a month the tubes will be sent to the collaborating laboratory for analysis.
Sponsors
Kovacs Foundation
Study design
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients referred to the Kovacs Back Pain Unit in Palma de Mallorca for chronic low back pain * A pain level of 6 or greater on the PI-NRS scale (0=no pain, 10= worst pain possible) * Seen at the Unit between 9 and 13 hours (due to the circadian rhythm of Substance P in saliva and to avoid great variability in the results) For healthy subjects: * Volunteers with no pain (anywhere) * That in the past year have had no more than 40 days with pain, and no episode of more than 7 days of continuous pain.
Exclusion criteria
* Subjects with pain that is additional to or different from chronic low back pain
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Levels of Substance P in the saliva | 12 months |
Countries
Spain
Outcome results
None listed