Wound Healing Abnormalities in Major Abdominal Surgery

Incidence of Wound-healing-abnormalities in Major Abdominal Surgery - Association With Factors of Coagulation

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00735579

Acronym

INWOUND

Enrollment

260

Registered

2008-08-15

Start date

2008-07-31

Completion date

2017-04-21

Last updated

2017-04-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Factor XIII Deficiency, Impaired Wound Healing

Keywords

major abdominal surgery, coagulation, extracellular matrix proteins, wound healing after major abdominal surgery

Brief summary

This clinical observational study investigates the incidence of wound healing abnormalities in patients undergoing major abdominal surgery. Second aim of the study is, if wound healing deficits may be accompanied by abnormalities in blood coagulation parameters.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

* Age \>= 18 years * Male or female * Informed consent * Major abdominal surgery

Exclusion criteria

* Pre-existing coagulation abnormalities * Pre-existing severe renal or liver failure * Chemo- or radiochemotherapy

Design outcomes

Primary

Measure	Time frame	Description
Incidence of wound healing abnormalities	from baseline to postoperative day 28	Occurence of wound healing abnormalities within the first 28 days after surgery

Secondary

Measure	Time frame	Description
Abnormalities in coagulation parameters	postoperative day 28	occurence of low platelets (\<60.000) or factor XIII \< 50% between the first and seventh postoperative day

Countries

Germany

Outcome results