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Comparing the Use of Vitamin c (Ascorbic Acid) in Eye Burn in Subconjunctival Injection to Topical or Oral Treatment.

The Effect of Subconjunctival Vitamin c on Recovery Rate and End Result From Eye Burn.

Status
Withdrawn
Phases
Phase 1
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00734695
Enrollment
20
Registered
2008-08-14
Start date
2009-07-31
Completion date
2010-02-28
Last updated
2010-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Burn

Keywords

BURN, EYE, VITAMIN C, ASCORBIC ACID

Brief summary

Eye burns may cause a severe permanent damage. One kind of treatment is the use of vitamin C (Ascorbic acid). This study will compare between subconjunctival topical and/or systemic route of administration and topical and/or systemic administration.

Detailed description

In order to prevent permanent and severe damage to the eye after eye burn early treatment is mandatory. It is well known and published that the use of Vitamin c may contribute to the healing process of such burns, including burns from chemicals or heat. We believe that the route pf administration of the medicine is as important as the kind of medicine and that subconjunctival injection will have better effect and will influence in a favorable manner on the the end result as well as on the time of the healing. In order to be able to compare between cases we made a new definition of the severity of the burn according to the extension of the damage on the cornea, conjunctiva and limbus, and according to the severity and depth of the ischemia. In 3 medical centers 3 protocols of treatment and followup will be compared while only in Baruch Pade Medical Center the main route of administration will be subconjunctival on top of the topical treatment.

Interventions

DIETARY_SUPPLEMENTvitamin c

Subconjunctival daily or bid

Sponsors

Rambam Health Care Campus
CollaboratorOTHER
Soroka University Medical Center
CollaboratorOTHER
The Baruch Padeh Medical Center, Poriya
Lead SponsorOTHER_GOV

Study design

Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
No minimum to 90 Years
Healthy volunteers
No

Inclusion criteria

* Eyes clinic patients presented with acute chemical or thermal burn.

Exclusion criteria

other disease

Design outcomes

Primary

MeasureTime frame
EXTENSION OF FLORSCEIN PAINT ON THE CORNEA AND CONJUNCTIVABID

Countries

Israel

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026