Inflammatory Response During Cardiac Surgery, Lung Dysfunction
Conditions
Keywords
COPD, CPB, Leukotrienes
Brief summary
The hypotheses of this study are that: * Production and release of inflammatory substances called leukotrienes are increased during heart surgery with use of a heart-lung machine in humans; * The increase in these leukotrienes levels after heart surgery is higher in patients with bronchitis and/or emphysema than in patients without previous history of lung disease; * Levels of leukotrienes are directly correlated with worsening of lung function during and after heart surgery.
Detailed description
In this project, we will test the hypothesis that cys-leukotrienes are released and correlated with the impairment of the lung function after cardiac surgery in patients with COPD. If such hypothesis is substantiated in the study, it would allow us to propose the use of leukotriene inhibitors in the peri-operative period to improve pulmonary function and to decrease complications after cardiac surgery in COPD patients.
Interventions
None listed
Sponsors
Merck Sharp & Dohme LLC
Massachusetts General Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients schedules to undergo cardiac surgery with use of CPB.
Exclusion criteria
* inability to provide consent; * previous diagnosis of asthma; * acute pre-operative respiratory failure; * emergency surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| urine cysteinyl leukotriene | intra-operative |
Outcome results
None listed