Healthy
Conditions
Keywords
Cortico-cortical, connectivity, Transcranial, Magnetic, Stimulation
Brief summary
The aim of the proposed research is to measure the effect of drug-induced sedation on the functional connectivity between brain regions as indicated by EEG signal transmission within the human brain. The results of this study will help to identify the neurophysiological correlates of changes in conscious experience that occur during drug-induced sedation.
Detailed description
In the proposed experiments cortical areas will be stimulated using low frequency, low-amplitude transcranial magnetic stimulation (TMS) in healthy human subjects during wakefulness and during drug-induced responsive sedation and unresponsive sedation. Simultaneously, high-density electroencephalography (Hd-EEG) will be recorded to evaluate the temporal and spatial characteristics of evoked responses and induced rhythms over the cortex.
Interventions
None listed
Sponsors
University of Wisconsin, Madison
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy right-handed men * Aged 18-35 * Non-smokers * No metallic implants
Exclusion criteria
* Younger than 18 or over the age of 35.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Defining the neurophysiological conditions that are necessary for conscious experience. | Immediate |
Secondary
| Measure | Time frame |
|---|---|
| Understanding the neurophysiological correlates of conditions associated with restricted conscious experience such as sedation and anesthesia. | Immediate |
Countries
United States
Outcome results
None listed