Abortion, Induced, Uterine Curettage
Conditions
Keywords
Local anesthetic, Propofol, Sevoflurane
Brief summary
Anesthesia during uterine curettage is a problem. Paracervical block is used in general for such an operation, though, the anesthetic efficacy is incomplete. Propofol is the short-lasting intravenous anesthetic administrated popularly. Sevoflurane is a new inhalational anesthetic well-known for it's easy come, easy go property. The investigators hypothesized that propofol, sevoflurane and paracervical block had different anesthetic efficacy during uterine curettage. Which one is the optimal selection for such operation needed to be evaluated.
Interventions
DRUGLidocaine
Paracervical injection of 2% Lidocaine to block associated nociception input
DRUGPropofol
Propofol 3mg/kg will be injected intravenously; 1 mg/kg will be added additionally for incomplete anesthesia
DRUGSevoflurane
Sevoflurane 8% for anesthesia induction, 2-3% as the maintenance
Sponsors
Nanjing Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
19 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* ASA status I-II * Performing abortion operation (medical- or surgical) * Requiring painless abortion
Exclusion criteria
* \< 19 yrs, and \>=45 yrs * History of central active drugs administration * Drug abuse * Hypertension * Diabetes * Any other chronic diseases * Allergy to the study drugs * Habit of over-volume alcohol drinking * Records of history of centrally active drug use and psychiatry * Any organic disorder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bispectral Index (BIS) value | 0, 5, 10, 20, 30min after anesthesia |
Secondary
| Measure | Time frame |
|---|---|
| Vital signs | 0, 5, 10, 15, 20, 25, 30min after anesthesia |
| Arterial blood gas analysis | 5min before operation; 1min and 5min after beginning of the operation |
| Pain intensity | 0, 5, 10, 20, 30min after surgical procedures |
| Intraoperative awareness | 0, 5, 10, 20, 30min after anesthesia |
| Side effects | 30min after operation |
| Uterine bleeding | 0min after completion of the operation; 1 hour after the operation |
| Cortisol level | 30min before operation; 1 and 5min during operation |
Countries
China
Outcome results
None listed