Congestive Heart Failure, Elderly, Endothelium-derived Factors
Conditions
Keywords
passive leg exercise, congestive heart failure, endothelium-derived factors, elderly
Brief summary
The purpose of this study is to determine the effect of passive exercise on systemic endothelial function in elderly patients with chronic heart failure.
Detailed description
Endothelial function is known to be impaired in patients with chronic heart failure (CHF) and impaired endothelial function has been reported to be associated with an increased mortality risk in those subjects. Although systemic exercise training has been demonstrated to improve endothelial dysfunction in patients with CHF, elderly patients with severely impaired exercise capacity could not engaged in usual exercise training using ordinal ergometer. Those patients are able to join stretching or very light resistance training. On the other hand, passive pedaling using strength ergometer has been reported to be useful in patients with severely impaired exercise capacity, but the safety and the efficacy of passive pedaling on endothelial function in old patients with CHF has not been previously reported.
Interventions
OTHERPassive leg cycle exercise with stretching and resistance training
Passive leg cycle exercise for 15 minutes everyday as well as stretching and resistance training
OTHERStretching and resistance training
Stretching and resistance training everyday but no Passive leg cycle exercise
Sponsors
Kyoto University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Clinical diagnosis of chronic heart failure * Elderly patients aged ≧65 years * Patients with severely reduced exercise capacity and cannot continue exercise with usual cycling ergometer for 5 minutes
Exclusion criteria
* Unstable hemodynamic status (uncontrolled arrhythmia, uncontrolled congestion, uncontrolled hypertension) * Active infectious disease * Malignancy * Chronic obstructive pulmonary disease * Dialysis * Severe aortic valve disease * With any hip, knee, ankle joint pain * Hemiplegia * Current smoker
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Endothelial function | 2 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Left ventricular systolic and diastolic function | 2 weeks |
| Six-minute walk distance | 2 weeks |
Countries
Japan
Outcome results
None listed