Cervical Intraepithelial Neoplasia
Conditions
Keywords
CIN2, management
Brief summary
The aim of this study was to compare two management options for CIN 2. This randomized clinical trial performed between 2003 and 2006. A series of 90 Brazilian women diagnosed as CIN2 were randomized into two groups: 1) 45 whose lesion was excised and,2) 45 women subjected to follow-up at 3-month intervals for 12 months.
Detailed description
Pap smear and colposcopy were performed at every follow-up visit and all lesions were completely visible at colposcopy. The researchers purpose was to make some comments about the over treatment and the misclassification of CIN 2.
Interventions
PROCEDUREExcision of the lesion
Surgery with Large Loop Excision of Transformation Zone (LLETZ)
OTHERFollow-up for spontaneous regression of the lesion
Follow-up at last 12 months
Sponsors
Fundação de Amparo à Pesquisa do Estado de São Paulo
Universidade Cidade de Sao Paulo
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 61 Years
Healthy volunteers
No
Inclusion criteria
* Histological CIN2 diagnosis
Exclusion criteria
* Previous CIN treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 43 women in the follow-up group, 44.1% experienced spontaneous regression, 20.9% had partial regression, 23.2% progressed to CIN3, and 11.6% showed persistence. 44 women whose lesion was excised, the regression rate was 90.9% | 12 months |
Countries
Brazil
Outcome results
None listed