Effects of Omega-3 Fatty Acids and Menaquinone-7 on Thrombotic Tendency

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00732576

Enrollment

Registered

2008-08-12

Start date

2008-01-31

Completion date

2008-05-31

Last updated

2017-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atherosclerosis

Keywords

Cardiovascular, Calcification

Brief summary

Omega-3 fatty acids are notably present in fish oil and krill oil, and are known to have beneficial effects on the vasculature. Vitamin K2 is known for preventing vascular calcification. In this study we investigate a potential synergy between the effects of either fish or krill oil and menaquinone-7, which is one of K2 vitamins.

Interventions

DIETARY_SUPPLEMENTmenaquinone-7

capsule consisting of 10, 20 or 45 µg menaquinone-7 per day during 8 weeks

DIETARY_SUPPLEMENTfish oil

9 fish oil capsules equivalent to 3 gram per day of n-3 polyunsaturated fatty acids during 12 weeks

DIETARY_SUPPLEMENTkrill oil

9 krill oil capsules, equivalent to 1,5 gram per day of n-3 polyunsaturated fatty acids (PUFA) during 12 weeks

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

25 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy subjects - BMI \< 30 * written informed consent

Exclusion criteria

* Use of oral anticoagulants * Coagulation disorders * Use of multivitamin supplements * Use of corticosteroids, anticonceptives * hypertriglyceridemia, hypercholesterolemia

Design outcomes

Primary

Measure	Time frame
Endogenous Thrombin Potential (ETP)	12 weeks

Secondary

Measure	Time frame
Osteocalcin carboxylation	12 weeks
Matrix Gla-protein carboxylation	12 weeks

Countries

Netherlands

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026