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Effect of Antioxidant on Endurance Performance in Healthy Men

Effect of Antioxidant on Endurance Performance in Healthy Men -Double Blind Randomized Placebo and Active Controlled Trial-

Status
Completed
Phases
Phase 2Phase 3
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00731926
Enrollment
69
Registered
2008-08-11
Start date
2007-09-30
Completion date
2008-02-29
Last updated
2008-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Exercise Tolerance

Brief summary

oligomerized litchi fruit extract may enhance the submaximal endurance exercise performance

Detailed description

Regular physical exercise has many beneficial effects, but it has been reported that strenuous exercise could elevate the production of free radical and other reactive oxygen species (ROS) which eventually injure the tissues and decrease the muscle function.So many kinds of antioxidant supplementations have been tried to decrease the muscle fatigue and enhance the exercise performance. polyphenolic flavonoids abundant in fruits and leafy vegetables have strong antioxidant effect. oligomerized litchi fruit extract has strong antioxidant capacity and higher bioavailability compared to that of grape seed polyphenol. The aim of this study was to determine whether oligomerized litchi fruit extract could induce endurance exercise performance more than Vit C + Vit E mixture or placebo could do. Therefore, we designed double blind randomized controlled trial, setting the change of running time to exhaustion under submaximal treadmill test as the primary endpoint.

Interventions

DIETARY_SUPPLEMENTOligomerized litchi fruit extract

100mg at once twice a day for 1 month

DIETARY_SUPPLEMENTVItamin C + Vitamin E mixture

Vitamin C 400mg + Vitamin E 160IU at once twice a day for 1 month

OTHERplacebo

twice a day for 1 month

Sponsors

University of California, Davis
CollaboratorOTHER
Seoul National University Hospital
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender
MALE
Age
20 Years to 50 Years
Healthy volunteers
Yes

Inclusion criteria

* healthy men over 20 years old non-smoker

Exclusion criteria

* BMI\>25 or body fat\>25% he who intakes the antioxidant supplement in recent 2 weeks

Design outcomes

Primary

MeasureTime frame
change of running time to exhaustion under 80% of maximal heart rate1 month

Secondary

MeasureTime frame
VO2max, anaerobic threshold1 month

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026