Sperm Capacitation
Conditions
Brief summary
Our aim is to evaluate the potential of a new laboratory method that measure sperm capacitation to predict fertilization of oocytes in patients that undergo IVF treatments
Detailed description
Capacitation is a physiologic process in which the sperm acquire the potential to fertilize oocytes. Capacitation can be measured, but the available technics are expensive, inaccurate and complex. A new method to evaluate sperm capacitation was developed in Bar Ilan University, Israel. We intend to measure the capacitation of semen that is used for fertilizing human oocytes in patients treated at the IVF unit at Assaf Harofeh Medical Center.By this, to evaluate the potential of the new method to predict human oocyte fertilization.If the method will be found valuable, it will enable to develop new drugs/methods that may improve sperm capacitation and by this to improve oocyte fertilization leading to more embryos, pregnancies and deliveries.
Interventions
BIOLOGICALsperm capacitation
sperm capacitation measured at Bar Ilan University
OTHERbiologic
sperm synthesis of G-actine to F-actine
Sponsors
Assaf-Harofeh Medical Center
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients requiring IVF within the routine work of an IVF Unit * normo-responding woman * non ICSI cycles
Exclusion criteria
* Patients undergoing ICSI only cycle * Low responders-less than 8 oocytes * Male patients with low semen volume
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fertilization rate of human oocytes in thr routine IVF Laboratory work | One year |
Countries
Israel
Contacts
Primary Contactarieh raziel, prof
Backup Contactraphael ron-el, prof
Outcome results
None listed