Cataract, Endophthalmitis
Conditions
Keywords
fibrin, endophthalmitis, cataract extraction, Lens, implantation,, intraocular
Brief summary
The study investigates whether placing an antibiotic inside the eye at the end of cataract surgery in children will reduce the amount of fibrin formation (fibrin formation can block the pupil and reduce vision). We hypothesize that the fibrin is caused by a low-level infection and could be prevented by the antibiotic.
Detailed description
The study investigates whether using an antibiotic (cefuroxime) in the anterior chamber of the eye at the end of surgery for cataract in children will reduce the amount of fibrin formation.
Interventions
DRUGcefuroxime
intracameral cefuroxime 0.1 ml
DRUGSaline placebo
0.1 ml of Ringers lactate
Sponsors
Presbyterian Church East Africa Kikuyu Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
6 Months to 15 Years
Healthy volunteers
No
Inclusion criteria
* bilateral congenital or developmental pediatric cataract
Exclusion criteria
* traumatic cataract
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fibrin formation in anterior chamber | 4th postoperative day |
Countries
Kenya
Outcome results
None listed