Association Study of Gene Polymorphisms With Cardiac Performance

Observational Association Study of G Protein Polymorphisms With Cardiac Performance in Coronary Artery Disease Patients Undergoing Coronary Artery Bypass Grafting

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00730899

Enrollment

500

Registered

2008-08-08

Start date

2008-05-31

Completion date

2011-06-30

Last updated

2008-08-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease, Genetic Polymorphism, Hemodynamics

Brief summary

The purpose of this study is to determine whether polymorphisms in G protein subunits, namely Galphas and Galphaq, are associated with altered cardiac performance in heart failure patients.

Detailed description

G Protein pathways plays a pivotal role in mediating positive inotropy and cardiac hypertrophy by transducing signals of neurohormones in cardiomyocytes. Single nucleotide polymorphisms (SNPs) in the G protein subunits Galphas and Galphaq have been shown to result in altered protein expression. We now want to examine whether G Protein polymorphisms alter NYHA functional class, and hemodynamic variables in patients with coronary artery disease scheduled for coronary artery bypass grafting .

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* clinical diagnosis of coronary artery disease * patients scheduled for coronary artery bypass grafting

Exclusion criteria

* emergency operation * combined vitium

Design outcomes

Primary

Measure	Time frame
genotype dependent change of hemodynamic variables	one day

Secondary

Measure	Time frame
all cause mortality	60 days

Countries

Germany

Contacts

Primary ContactUlrich H Frey, MD

ulrich.frey@uk-essen.de+49201723

Outcome results