Non-Alcoholic Fatty Liver Disease, Obstructive Sleep Apnea
Conditions
Brief summary
Non-alcoholic fatty liver disease is associated with obstructive sleep apnea. Abnormalities in liver enzymes can improve following continuous positive airway pressure in patients with obstructive sleep apnea. Computerized tomography can be used to quantify fatty liver changes. We hypothesize that continuous positive airway pressure can reduce morphologic fatty liver changes in patients with obstructive sleep apnea and non-alcoholic fatty liver, an that this reduction can be evident using computerized tomography
Interventions
DEVICEContinuous positive airway pressure
Sponsors
Assaf-Harofeh Medical Center
Study design
Primary purpose
TREATMENT
Eligibility
Sex/Gender
ALL
Age
30 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Obstructive sleep apnea, defined as AHI\>5/h
Exclusion criteria
* Consumption of more than 20 grams of alcohol per 24 h * Known autoimmune disease * Usage of known hepatotoxic drugs * Medical history positive for viral hepatitis or other chronic liver disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in fatty liver changes on computerized tomography | Within 1-2 years |
Secondary
| Measure | Time frame |
|---|---|
| Improved liver enzymes abnormalities | Within 1-2 years |
Countries
Israel
Outcome results
None listed