Study on Clinical Outcome of Vascular Inflow Occlusion in Open Liver Resection

Open Liver Resection With or Without Vascular Inflow Occlusion: a Randomized Control Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00730743

Enrollment

126

Registered

2008-08-08

Start date

2008-05-31

Completion date

2011-08-31

Last updated

2015-02-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatectomy

Brief summary

This study aims to evaluate whether applying inflow vascular occlusion in modern liver resection is associated with better clinical outcome. Eligible patients are randomly assigned to the two surgical techniques: with or without the application of inflow vascular occlusion. Patients outcome including liver function recovery, operative time and blood loss are compared.

Interventions

PROCEDUREIntermittent Pringle maneuver

Pringle maneuver is performed by isolation of the hepatoduodenal ligament which is then encircled and occluded with atraumatic vascular clamp. The clamp is applied for 15 minutes followed by unclamping for 5 minutes and repeated till end of liver transection. Limits of clamp cycle: 3 cycles for cirrhotic liver; 4 cycles for non-cirrhotic liver.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age \> 18 years * Child-Pugh Class A or B

Exclusion criteria

* Informed consent not available * Presence of portal vein thrombosis, portal vein tumor thrombus, or previous portal vein embolisation * Presence of hepatic artery thrombosis, previous transarterial therapy like TACE, or transarterial internal radiation * When portal vein resection is anticipated * Emergency hepatectomy * Ruptured hepatocellular carcinoma * Rehepatectomy (repeated liver resection) * Adhesion or anatomical variation that preclude safe and successful application of Pringle maneuver * When concomitant bowel or bile duct resection is anticipated

Design outcomes

Primary

Measure	Time frame
Operative blood loss	From skin incision to completion of operation
Operative time	From skin incision to completion of operation

Secondary

Measure	Time frame
Operative morbidity and mortality	From date of operation to 30-day after operation
Recovery of liver function	From date of operation to date of discharge

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 25, 2026