Clonidine-Remifentanil. Effect of the Combination on Acute Pain and Respiration in Healthy Volunteers

Status

Completed

Phases

Phase 1Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00730054

Acronym

Remiclon

Enrollment

Registered

2008-08-08

Start date

2005-02-28

Completion date

2005-05-31

Last updated

2011-07-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Pain, Respiration, Sedation

Keywords

Remifentanil, clonidine, acute pain, respiration, sedation, cognitive function

Brief summary

The hypothesis is that systemic remifentanil and Clonidine act in a synergistic manner to relief acute main in an experimental human pain model. Of interest is also the effect of the combination on respiration, sedation and cognitive behavior.

Detailed description

To examine the possible synergistic effects og systemic remifentanil and clonidine. Its effects on respiration, cognitive function and sedation.

Interventions

DRUGRemifentanil+clonidine

iv Remifentanil+ iv clonidine

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy volunteers

Exclusion criteria

Design outcomes

Primary

Measure	Time frame
Relief of pain(VAS reduction)	Experimental

Secondary

Measure	Time frame
Reduction in Minute ventilation	Experimental
Reduction in CO2 stimulated Minute Ventilation	experimental
Reduction in BIS score	Experimental
Performance on Stroop test	Experimental

Countries

Norway

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026