Migraines, Vomiting
Conditions
Keywords
Genome Wide Scan (GWS), Mitochondrial scan, Family trios
Brief summary
The purpose of this study is to determine if there are genetic variations that can explain a genetic basis for cyclic vomiting syndrome (CVS).
Detailed description
The purpose of this study is to determine if there are genetic variations that can explain a genetic basis for cyclic vomiting syndrome (CVS), various phenotypes of CVS (e.g. menstrual, Sato, calendar-tied) and migraine headaches (e.g. with aura, without aura, hemiplegic migraine). This information will allow physicians to improve care for patients who have been diagnosed with this disease and to provide their parents with more complete information regarding the cause of this disease. This research is being done because many unanswered questions remain regarding children with CVS.
Interventions
None listed
Sponsors
Children's Hospital and Health System Foundation, Wisconsin
Medical College of Wisconsin
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 21 Years
Healthy volunteers
No
Inclusion criteria
* Subjects age 0-21 years old with CVS (different phenotypes). Each patient's authorized legal guardian must understand the nature of the study and must provide written informed consent.
Exclusion criteria
* Subjects age \> 22 years old Vomiting is not due to CVS or other related condition
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Identify novel genes that contribute to the risk of CVS using genomewide association analysis approach. | 3 years |
Secondary
| Measure | Time frame |
|---|---|
| Perform genotype-phenotype correlations between genetic profiles and various phenotypes of CVS (e.g. menstrual, Sato, calendar-tied) and migraine headaches (e.g. with aura, without aura, hemiplegic migraine) | 3 years |
Countries
United States
Outcome results
None listed