Comparison of Coronary CT Angiography With Conventional Coronary Angiography in Liver and Lung Transplant Candidates

Comparison of Coronary CT Angiography With Conventional Coronary Angiography in Liver and Lung Transplant Candidates.

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00727051

Enrollment

Registered

2008-08-01

Start date

2007-06-30

Completion date

2014-07-31

Last updated

2019-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease

Keywords

invasive coronary angiography, multidetector coronary CTA, coronary artery disease, detecting coronary artery disease

Brief summary

The overall goal of this study is to determine if non-invasive imaging with state of the art CT coronary angiography can be used to screen for coronary artery disease in high risk patients prior to liver and lung transplantation. The current protocol for coronary artery disease assessment at UCSF before liver and lung transplantation involves screening with stress tests and/or coronary angiograms in patients with increased risk of coronary artery disease. Coronary angiogram will be used as gold standard for assessment of coronary CTA accuracy.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Liver transplant candidates referred for invasive coronary angiography which include: * Patients with suspicious symptoms for CAD or; * Asymptomatic patients; * Abnormal non-invasive testing or 1 major risk factor for coronary artery disease or LVEF \< 60% on echo. 2. Lung transplant candidates referred for invasive coronary angiography which include: * Patients with suspicious symptoms for CAD or; * Asymptomatic patients; * Abnormal non-invasive testing or 1 major risk factor for coronary artery disease or LVEF \< 60% on echo in patients with low SVR (typical for ESLD). 3. Any ethnic background is acceptable.

Exclusion criteria

1. Patients with contraindications for the use of iodinated contrast (allergic reaction, renal failure, multiple myeloma, etc) will be excluded. 2. Children and pregnant women will be excluded because of risks associated with radiation exposure. 3. Patients must have no atrial fibrillation, as this will interfere with cardiac gating for the examination. 4. Patients unable to give informed consent will be excluded as well.

Design outcomes

Primary

Measure	Time frame
patients suspected of having coronary artery disease (CAD)	1-30 days before invasive coronary angiography is performed

Countries

United States

Outcome results