Obesity
Conditions
Keywords
Obesity, diet, carbohydrate, insulin
Brief summary
High levels of the hormone insulin are associated with risk for heart disease and diabetes, and may make it hard to lose weight. The types of food eaten may affect insulin levels. The purpose of this study is to determine if manipulation of dietary carbohydrate content improves insulin sensitivity (Si), augments weight loss, and promotes weight loss maintenance in healthy adults.
Interventions
DIETARY_SUPPLEMENTLow carbohydrate
43% CHO
Sponsors
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
University of Alabama at Birmingham
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
21 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
Overweight, age 21-50 years,Women must be premenopausal, Normal glucose tolerance, weight stable for at least 6 months with a weight change no greater than 5 lbs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Insulin sensitivity | IVGTT and minimal model |
Secondary
| Measure | Time frame |
|---|---|
| Weight loss | Weight loss over 8 weeks |
Countries
United States
Outcome results
None listed