Admixture Mapping of Ethnic and Racial Insulin Complex Outcomes

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00726778

Acronym

AMERICO

Enrollment

360

Registered

2008-08-01

Start date

2004-05-31

Completion date

2010-12-31

Last updated

2011-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

race/ethnicity, insulin senistivity, genetic admixture, type 2 diabetes, obesity, body composition, Insulin dynamics, Racial/ethnic differences

Brief summary

The main objective of this study is to investigate the effect of genetic and environmental parameters on racial/ethnic differences in aspects of insulin secretion and action. The genetic component will be modeled by estimating the degree of European genetic admixture (ADM) obtained from approximately 50 ancestry informative markers (AIMs). The environmental components will be modeled by measuring energy intake (food intake), energy expenditure (physical activity) and socioeconomic status.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

7 Years to 12 Years

Healthy volunteers

Yes

Inclusion criteria

* African American, European American, or Hispanic American, aged 7-12, healthy, weight is equal to or greater than 25 Kg

Exclusion criteria

* Type 1 or 2 diabetes, polycystic ovary disease, disturbances in glucose or lipid metabolism disturbances * Use of medication known to affect body composition or physical activity, diagnosis of genetic disorders known to affect body composition or fat distribution * Use of tobacco, alcohol consumption in excess of 400 g per week * Menstruated for more than a year prior to the recruitment; OR * A medical history that counter-indicates inclusion of the study

Design outcomes

Primary

Measure	Time frame
To test the role of European genetic admixture on measures of insulin action and response in a multiethnic group of prepubertal children.	5 years
To investigate whether the impact of energy intake, energy expenditure and socioeconomic status on proxy measures of insulin sensitivity and/or action differ as a function of European ADM in prepubertal children	5 years
To test phenotype-genotype associations between each one of the AIMs and measures of FI, SI and AIRg after adjusting for body composition in a sample of AA, HA and EA prepubertal children.	5 years

Countries

United States

Outcome results