Ventilator Associated Pneumonia
Conditions
Keywords
Ventilator associated Pneumonia, mechanically ventilated, procalcitonin, pneumonia scores
Brief summary
The purpose of this study is to test a new method for diagnosing and monitoring Ventilator-Associated Pneumonia, which is a major killer among ICU patients. The method requires analysis of a small amount of the patient's blood for concentration of a hormone called Procalcitonin.
Detailed description
Ventilator-associated pneumonia is a leading cause of mortality in critically ill patients. The purpose of this study is to evaluate the relationship between the onset/progress/resolution of pneumonia and the levels of Procalcitonin, a prohormone whose concentrations fluctuate in response to bacterial infection.
Interventions
DEVICEProcalcitonin Level
Procalcitonin concentrations will be determined every day and will be compared with the clinical diagnosis based upon standard clinical practice. All subjects enrolled will be followed until the patient is either extubated or discharged from the SICU.
Sponsors
University of Missouri-Columbia
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Are willing to give or who's proxy is willing to consent to be a study subject * Are at least 18 years of age; * Who are mechanically ventilated surgical intensive care unit patients.
Exclusion criteria
* Participation in any investigational device or drug trial within 30 days prior to enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Correlation of Procalcitonin concentration with the LungGuardian-derived Pneumonia Score in mechanically ventilated surgical intensive care unit patients. Using the data collected a positive and negative predictive value will be calculated. | Once daily |
Secondary
| Measure | Time frame |
|---|---|
| antibiotic status (appropriateness, effectiveness, discontinuation criteria) | Once daily |
| intubation date | Once daily |
| microbiology data | Once daily |
| PCT levels | Once daily |
| pneumonia-related symptoms (including tracheal secretion character, body temperature, oxygenation, and WBC counts) | Once daily |
Countries
United States
Outcome results
None listed